N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺

中文名	LMK 235
英文名	LMK 235
别名	HDAC抑制剂(LMK-235) N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺
英文别名	LMK235 CS-1820 LMK 235 LMK-235 LMK 235 LMK-235 (Fandachem) N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl- N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide LMK-235
CAS	1418033-25-6
EINECS	808-770-7
化学式	C15H22N2O4
分子量	294.35
InChIKey	VRYZCEONIWEUAV-UHFFFAOYSA-N
密度	1.155±0.06 g/cm3(Predicted)
熔点	135-138°C
溶解度	DMSO: 可溶20mg/mL，澄清
酸度系数	9.46±0.20(Predicted)
存储条件	2-8°C
外观	粉末
颜色	white to beige
产品用途	LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. LMK-235 demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μ M respectively).
靶点	HDAC4; HDAC5;
危险品标志	Xn - 有害物品
风险术语	22 - 吞食有害。
WGK Germany	3
上游原料	BENZYL 6-BROMOHEXANOATE
参考资料展开查看	1: Hansen FK, Sumanadasa SD, Stenzel K, Duffy S, Meister S, Marek L, Schmetter R, Kuna K, Hamacher A, MordmÃ¼ller B, Kassack MU, Winzeler EA, Avery VM, Andrews KT, Kurz T. Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. Eur J Med Chem. 2014 Jul 23;82:204-13. doi: 10.1016/j.ejmech.2014.05.050. Epub 2014 May 22. PubMed PMID: 24904967. 2: Marek L, Hamacher A, Hansen FK, Kuna K, Gohlke H, Kassack MU, Kurz T. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J Med Chem. 2013 Jan 24;56(2):427-36. doi: 10.1021/jm301254q. Epub 2013 Jan 8. PubMed PMID: 23252603.

N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.397 ml	16.987 ml	33.973 ml
5 mM	0.679 ml	3.397 ml	6.795 ml
10 mM	0.34 ml	1.699 ml	3.397 ml
5 mM	0.068 ml	0.34 ml	0.679 ml

最后更新：2024-01-02 23:10:35

N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺 - 细胞实验

The rate of cell survival under the action of test substances is evaluated by an improved MTT assay. The assay is based on the ability of viable cells to metabolize yellow MTT to violet formazan that can be detected spectrophotometrically. In brief, A2780, Cal27, Kyse510, and MDA-MB-231 cell lines are seeded at a density of 5000, 7000, 8000, and 10 000 cells/well in 96-well plates. After 24 h, cells are exposed to increased concentrations of the test compounds. Incubation is ended after 72 h, and cell survival is determined by addition of MTT solution (5 mg/mL in phosphate buffered saline). The formazan precipitate is dissolved in DMSO. Absorbance s measured at 544 and 690 nm in a FLUOstar microplate reader. (Only for Reference)

最后更新：2023-08-16 21:32:38

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产品名: N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺去供应商网站查看询盘
CAS: 1418033-25-6
产地: 上海
规格: L873791
价格: 10mg-483,25mg-946,100mg-2423,1ml-720
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产品名: N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺去供应商网站查看询盘
CAS: 1418033-25-6
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包装: 10mg
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产品描述: 中文名：N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺英文名:LMK 235 CAS:1418033-25-6 规格:98% 产地: 更多

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产品名: LMK 235 去供应商网站查看询盘
CAS: 1418033-25-6
产地: 上海
规格: 99%
价格: 5mg 400,10mg 650,25mg 1250,100mg 3700
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